The 90s was an interesting time for biology research as researchers shifted from reductionist to a systems approach for studying and understanding biological systems. A decade later, high-throughput technologies revolutionized the field of systems biology by generating heaps of data. Thanks to these technologies, the state of thousands of genes, proteins, chemicals or metabolites at a given time-point, or in response to any stimuli, can be captured now. However, generating insights from this humongous amount of data was like looking for a needle in a haystack.